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Kembali| NIM (Student Number) | I1B015046 |
|---|---|
| Nama Mahasiswa | MAHATI ULFAH |
| Judul Artikel | EFEK PEMBERIAN SEDUHAN TANAMAN SIRIH CINA (Peperomia pellucida) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS PUTIH JANTAN HIPERKOLESTEROLEMIA |
| Abstrak | Latar Belakang: Mengkonsumsi makanan tinggi lemak secara berlebihan dapat menyebabkan hiperkolesterolemia. Hiperkolesterolemia yang berlangsung lama dapat menimbulkan arterosklerosis sehingga mengkibatkan terjadinya Penyakit Jantung Koroner (PJK). Tanaman sirih cina mengandung banyak senyawa aktif seperti flavonoid, tanin, saponin dan alkaloid yang diduga dapat menurunkan kadar kolesterol total dalam darah. Tujuan: Mengetahui efek pemberian seduhan tanaman sirih cina terhadap kadar kolesterol total dan pemberian dosis paling efektif. Metode: Penelitian eksperimental ini menggunakan metode true experiment pretest-postest with control group design. Total sampel 36 ekor tikus Wistar jantan dibagi 6 kelompok (A kontrol sehat, B kontrol negatif, C perlakuan dosis 150 mg/kgBB, D dosis 300 mg/kgBB, E dosis 600 mg/kgBB dan F simvastatin 0,18 mg/200gBB). Induksi diberikan selama 7 hari dengan pakan standar dan campuran kuning telur bebek dengan jus hati ayam. Intervensi selama 14 hari pada perlakuan sesuai dosis. Uji hipotesis one way ANOVA dilanjutkan post hoc Duncan. Hasil: Kelompok perlakuan dengan seduhan tanaman sirih cina memiliki efek menurunkan kadar kolesterol total. Hasil uji one way ANOVA posttest menunjukan nilai p< 0,05 dan dosis 600 mg/kgBB paling efektif. Kesimpulan: Terdapat efek pemberian seduhan tanaman sirih cina terhadap kadar kolesterol total dengan dosis paling efektif 600 mg/kgBB. Kata kunci: seduhan, peperomia pellucida, kolesterol total |
| Abstrak (Inggris) | Abstract Background back: Consume food high fat in manner excessive could cause hypercholesterolemia. Hypercholesterolemia that can last a long time raises atherosclerosis so that cause occurrence Coronary Heart Disease (CHD). Sirih cina plant contain many compound active like flavonoids, tannins, saponins and suspected alkaloid could bring down grade deep total cholesterol blood. Purpose: Knowing effect gift steeping sirih cina plant to grade total cholesterol and gift the most effective dose. Method: Research experimental this use method true experiment with pretest-postest control group design. The total sample is 36 tails rat wistar male divided into 6 groups (A control healty, B control negative, C treatment dose of 150 mg/kg body weight, D dose of 300 mg/kg body weight, E dose 600 mg/kg body weight and F simvastatin 0,18 m/200g body weight). Induction given for 7 days with feed standard and mixture yellow egg duck with liver juice chicken. Intervention for 14 days on treatment corresponding dose. Test hypothesis one way ANOVA continued Duncan’s post hoc. Results: Group treatment with steeping sirih cina plant have effect bring down grade total cholesterol. Results posttest one way ANOVA test showing p value <0,05 and the most effective dose of 600 mg/kg body weight. Conclusion: Is available effect gift steeping sirih sina plant to grade total cholesterol with the mos effective dose is 600mg/kg body weight. Keywords: steeping, Peperomia pellucida , total cholesterol. |
| Kata Kunci | peperomia pellucida, kolesterol total |
| Nama Pembimbing 1 | Dr. Saryono, S. Kp., M. Kes., |
| Nama Pembimbing 2 | Ns. Agis Taufik M.Kep., Sp. Kep. MB., |
| Tahun | 2019 |
| Jumlah Halaman | 12 |
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